BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response
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چکیده
منابع مشابه
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) stress signalling through the regulation of the ER stress sensor inositol requiring kinase 1 α (IRE1α). Here, we describe a novel function of BI-1 in the modulation of autophag...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.318